Publication

Nuclear reorganization by NPM1-mediated phase separation triggered by adenovirus core protein VII.

Genoveso MJ, Okuwaki M, Kato K, Nagata K, Kawaguchi A. Microbiol Spectr. 2024 Aug 20:e0041624. doi: 10.1128/spectrum.00416-24.

Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs.

Breidenbach J, Voget R, Si Y, Hingst A, Claff T, Sylvester K, Wolf V, Krasniqi V, Useini A, Sträter N, Ogura Y, Kawaguchi A, Müller CE, Gütschow M. J Med Chem. 2024 May 16. doi: 10.1021/acs.jmedchem.4c00053.

Detection of Active SARS-CoV-2 3CL Protease in Infected Cells Using Activity-Based Probes with a 2,6-Dichlorobenzoyloxymethyl Ketone Reactive Warhead.

Yamauchi Y, Konno S, Omura N, Yoshioka N, Hingst A, Gütschow M, Müller CE, Taguchi A, Taniguchi A, Kawaguchi A, Hayashi Y. ACS Chem Biol. 2024 May 17;19(5):1028-1034. doi: 10.1021/acschembio.4c00024.

Di-n-butyl phthalate promotes the neural differentiation of mouse embryonic stem cells through neurogenic differentiation 1.

Lin YC, Wuputra K, Kato K, Ku CC, Saito S, Noguchi M, Nakamura Y, Hsiao M, Lin CS, Wu DC, Kawaguchi A, Yu HS, Yokoyama KK. Environ Pollut. 2024 Apr 15;347:123722. doi: 10.1016/j.envpol.2024.123722.

Intramolecular interaction of NEP regulated by CRM1 ensures the unidirectional transport of M1 for the nuclear export of influenza viral ribonucleoprotein

Hirohama M, Yamashita S, Asaka MN, Kuroki T, Kawaguchi A. Front Virol., 2023 Aug 17. doi: 10.3389/fviro.2023.1232906

Systematic Surveillance of an Emerging Picornavirus among Cattle and Sheep in China.

Ji C, Zhang Y, Feng Y, Zhang X, Ma J, Pan Z, Kawaguchi A, Yao H. Microbiol Spectr. 2023 Jun 15;11(3):e0504022. doi: 10.1128/spectrum.05040-22.

Zinc binding of a Cys2His2-type zinc finger protein is enhanced by the interaction with DNA.

Hajdu B, Hunyadi-Gulyás É, Kato K, Kawaguchi A, Nagata K, Gyurcsik B. J Biol Inorg Chem. 2023 Apr;28(3):301-315. doi: 10.1007/s00775-023-01988-1.

TMPRSS2 gene polymorphism common in East Asians confers decreased COVID-19 susceptibility.

Sekiya T, Ogura Y, Kai H, *Kawaguchi A, Okawa S, Hirohama M, Kuroki T, Morii W, Hara A, Hiramatsu Y, Hitomi S, Kawakami Y, Arakawa Y, Maruo K, Chiba S, Suzuki H, Kojima H, Tachikawa H, *Yamagata K. Front Microbiol. 2022 Nov 30;13:943877. doi: 10.3389/fmicb.2022.943877. *equal corresponding

Nano-visualization of the in vitro antiviral activity of black tea based on production area using a liposome-based virus membrane model.

Iijima M, Kawaguchi A, Ogura Y, Yoshimoto R, Kaneda M, Kera K, Kuroda S, Nakayama T. Biosci Biotechnol Biochem. 2022 Nov 23;86(12):1658-1669. doi: 10.1093/bbb/zbac163.

G307S DNAM-1 Mutation Exacerbates Autoimmune Encephalomyelitis via Enhancing CD4+ T Cell Activation.

Murata R, Kinoshita S, Matsuda K, Kawaguchi A, Shibuya A, Shibuya K. J Immunol. 2022 Nov 2:ji2200608. doi: 10.4049/jimmunol.2200608.

Ubiquitin-specific protease TRE17/USP6 promotes tumor cell invasion through the regulation of glycoprotein CD147 intracellular trafficking.

Ogura Y, Ohbayashi N, *Kanaho Y, *Kawaguchi A, *Funakoshi Y. J Biol Chem. 2022 Sep;298(9):102335. doi: 10.1016/j.jbc.2022.102335. *equal corresponding

ARHGAP1 Transported with Influenza Viral Genome Ensures Integrity of Viral Particle Surface through Efficient Budozone Formation.

Kuroki T, Hatta T, Natsume T, Sakai N, Yagi A, Kato K, Nagata K, Kawaguchi A. mBio. 2022 Jun 28;13(3):e0072122. doi: 10.1128/mbio.00721-22.

3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents.

Konno S, Kobayashi K, Senda M, Funai Y, Seki Y, Tamai I, Schäkel L, Sakata K, Pillaiyar T, Taguchi A, Taniguchi A, Gütschow M, Müller CE, Takeuchi K, Hirohama M, Kawaguchi A, Kojima M, Senda T, Shirasaka Y, Kamitani W, Hayashi Y. J Med Chem. 2022 Feb 24;65(4):2926-2939. doi: 10.1021/acs.jmedchem.1c00665

Template activating factor-I epigenetically regulates the TERT transcription in human cancer cells.

Kato K, Kawaguchi A, Nagata K. Sci Rep. 2021 Sep 6;11(1):17726. doi: 10.1038/s41598-021-97009-9.

Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes.

Lee S, Ishitsuka A, Kuroki T, Lin YH, Shibuya A, Hongu T, Funakoshi Y, Kanaho Y, Nagata K, Kawaguchi A. JCI Insight. 2021 Aug 23;6(16):e139190. doi: 10.1172/jci.insight.139190.

Potent mouse monoclonal antibodies that block SARS-CoV-2 infection.

Guo Y, Kawaguchi A, Takeshita M, Sekiya T, Hirohama M, Yamashita A, Siomi H, Murano K. J Biol Chem. 2021 Jan-Jun;296:100346. doi: 10.1016/j.jbc.2021.100346.

Interaction of influenza A virus NS2/NEP protein with the amino-terminal part of Nup214.

Şenbaş Akyazi B, Pirinçal A, Kawaguchi A, Nagata K, Turan K. Turk J Biol. 2020 Apr 2;44(2):82-92. doi: 10.3906/biy-1909-49.

Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium.

Lee S, Ishitsuka A, Noguchi M, Hirohama M, Fujiyasu Y, Petric PP, Schwemmle M, Staeheli P, Nagata K, Kawaguchi A. Sci Immunol. 2019 Oct 25;4(40):eaau4643. doi: 10.1126/sciimmunol.aau4643.

Involvement of CTCF in transcription regulation of EGR1 at early G1 phase as an architecture factor.

Sekiya T, Kato K, Kawaguchi A, Nagata K. Sci Rep. 2019 Jan 23;9(1):329. doi: 10.1038/s41598-018-36753-x.

Influenza A Virus NS1 Protein Suppresses JNK1-Dependent Autophagosome Formation Mediated by Rab11a Recycling Endosomes.

Kuroki T, Osari S, Nagata K, Kawaguchi A. Front Microbiol. 2018 Dec 14;9:3120. doi: 10.3389/fmicb.2018.03120.

Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma.

Kim Y, Shiba-Ishii A, Nakagawa T, Iemura SI, Natsume T, Nakano N, Matsuoka R, Sakashita S, Lee S, Kawaguchi A, Sato Y, Noguchi M. Oncogene. 2018 Oct;37(40):5387-5402. doi: 10.1038/s41388-018-0342-9.

Biochemical characterization of avian influenza viral polymerase containing PA or PB2 subunit from human influenza A virus.

Pham PTV, Turan K, Nagata K, Kawaguchi A. Microbes Infect. 2018 Jun-Jul;20(6):353-359. doi: 10.1016/j.micinf.2018.04.003.

Influenza A Virus Infection Triggers Pyroptosis and Apoptosis of Respiratory Epithelial Cells through the Type I Interferon Signaling Pathway in a Mutually Exclusive Manner.

Lee S, Hirohama M, Noguchi M, Nagata K, Kawaguchi A. J Virol. 2018 Jun 29;92(14):e00396-18. doi: 10.1128/JVI.00396-18.

Inhibition of Influenza Virus Infection by Lentinus edodes Mycelia Extract Through Its Direct Action and Immunopotentiating Activity.

Kuroki T, Lee S, Hirohama M, Taku T, Kumakura M, Haruyama T, Nagata K, Kawaguchi A. Front Microbiol. 2018 May 29;9:1164. doi: 10.3389/fmicb.2018.01164.

Assembly and remodeling of viral DNA and RNA replicons regulated by cellular molecular chaperones.

Sekiya T, Hu Y, Kato K, Okuwaki M, Kawaguchi A, Nagata K. Biophys Rev. 2018 Apr;10(2):445-452. doi: 10.1007/s12551-017-0333-z.

Analysis by metadynamics simulation of binding pathway of influenza virus M2 channel blockers.

Sakai Y, *Kawaguchi A, Nagata K, *Hirokawa T. Microbiol Immunol. 2018 Jan;62(1):34-43. doi: 10.1111/1348-0421.12561. * equal corresponding

Cellular splicing factor UAP56 stimulates trimeric NP formation for assembly of functional influenza viral ribonucleoprotein complexes.

Hu Y, Gor V, Morikawa K, Nagata K, Kawaguchi A. Sci Rep. 2017 Oct 25;7(1):14053. doi: 10.1038/s41598-017-13784-4.

RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity.

Yoshizumi T, Imamura H, Taku T, Kuroki T, Kawaguchi A, Ishikawa K, Nakada K, Koshiba T. Sci Rep. 2017 Jul 14;7(1):5379. doi: 10.1038/s41598-017-05808-w.

Mitotic phosphorylation of CCCTC-binding factor (CTCF) reduces its DNA binding activity.

Sekiya T, Murano K, Kato K, Kawaguchi A, Nagata K. FEBS Open Bio. 2017 Jan 25;7(3):397-404. doi: 10.1002/2211-5463.12189.

Pre-mRNA Processing Factor Prp18 Is a Stimulatory Factor of Influenza Virus RNA Synthesis and Possesses Nucleoprotein Chaperone Activity.

Minakuchi M, Sugiyama K, Kato Y, Naito T, Okuwaki M, Kawaguchi A, Nagata K. J Virol. 2017 Jan 18;91(3):e01398-16. doi: 10.1128/JVI.01398-16.

Polycomb repressive complex 2 facilitates the nuclear export of the influenza viral genome through the interaction with M1.

Asaka MN, Kawaguchi A, Sakai Y, Mori K, Nagata K. Sci Rep. 2016 Sep 20;6:33608. doi: 10.1038/srep33608.

The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion.

Moriyama M, Chen IY, Kawaguchi A, Koshiba T, Nagata K, Takeyama H, Hasegawa H, Ichinohe T. J Virol. 2016 Mar 28;90(8):4105-4114. doi: 10.1128/JVI.00120-16.

Influenza Virus Induces Cholesterol-Enriched Endocytic Recycling Compartments for Budozone Formation via Cell Cycle-Independent Centrosome Maturation.

Kawaguchi A, Hirohama M, Harada Y, Osari S, Nagata K. PLoS Pathog. 2015 Nov 17;11(11):e1005284. doi: 10.1371/journal.ppat.1005284.

pp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA.

Sugiyama K, Kawaguchi A, Okuwaki M, Nagata K. eLife. 2015 Oct 29;4:e08939. doi: 10.7554/eLife.08939.

Oseltamivir expands quasispecies of influenza virus through cell-to-cell transmission.

Mori K, Murano K, Ohniwa RL, Kawaguchi A, Nagata K. Sci Rep. 2015 Mar 16;5:9163. doi: 10.1038/srep09163.

Centrosome maturation requires YB-1 to regulate dynamic instability of microtubules for nucleus reassembly.

Kawaguchi A, Asaka MN, Matsumoto K, Nagata K. Sci Rep. 2015 Mar 5;5:8768. doi: 10.1038/srep08768.

Actin-myosin network is required for proper assembly of influenza virus particles.

Kumakura M, Kawaguchi A, Nagata K. Virology. 2015 Feb;476:141-150. doi: 10.1016/j.virol.2014.12.016.

Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli.

Imamura K, Imamachi N, Akizuki G, Kumakura M, Kawaguchi A, Nagata K, Kato A, Kawaguchi Y, Sato H, Yoneda M, Kai C, Yada T, Suzuki Y, Yamada T, Ozawa T, Kaneki K, Inoue T, Kobayashi M, Kodama T, Wada Y, Sekimizu K, Akimitsu N. Mol Cell. 2014 Feb 6;53(3):393-406. doi: 10.1016/j.molcel.2014.01.009.